This website aims to increase healthcare professional awareness of how Niemann-Pick type C (NP-C) might present and help you understand which symptoms. Niemann-Pick (NP) es una enfermedad lisosomal transmitida por herencia ( ). Enfermedad de Niemann-Pick tipo C. Revista Mexicana de Neurociencia . Keywords: Niemann-Pick (NP) disease, miglustat, clinical trial, treatment. Go to: .. Enfermedad de Niemann-Pick tipo C. Revista Mexicana de Neurociencia.

Author: Kelar Kazrahn
Country: Sudan
Language: English (Spanish)
Genre: Photos
Published (Last): 23 March 2004
Pages: 490
PDF File Size: 17.65 Mb
ePub File Size: 17.5 Mb
ISBN: 806-7-29424-999-8
Downloads: 34989
Price: Free* [*Free Regsitration Required]
Uploader: Daisar

The trial of Heron et al.

Most notably, the clinical phenotype of the double mutant mice, in the absence of CNS ganglioside accumulation and associated neuronal pathology, did not improve. All authors; VI Manuscript writing: In some cases a psychosis may be the only manifestation for several years; the treatment by psychotropic drugs raises the question of a superimposition of a drug-induced lipidosis.

Niemann-Pick disease type C has a highly variable clinical phenotype.

Int J Surg ; 8: They suggested that formal esterification studies and mutation analysis should be performed, especially if prenatal testing is to be done in subsequent pregnancies. Please review our privacy policy. Cholesterol accumulation in tissues of the Niemann-Pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ.

Purkinje cells in both vulnerable and resistant subpopulations displayed no electrophysiologic abnormalities prior to degeneration. Partly conceived as a single arm, non-controlled, multi-centre, open label clinical trial and partly as an observational study. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. The trial carried out by Wraith et al. Orphanet J Rare Dis ; In a study of a single large kindred with NPD, Greer et al.


Although some biochemical differences may exist between type C and type D Niemann-Pick disease, both show evidence of defective regulation of intracellular cholesterol esterification and storage.

Niemann-Pick type C – Health Care Professionals Info

Cholestatic jaundice occurs in some patients. Long-term efficacy of miglustat in paediatric patients with Niemann-Pick disease type C. To assess the available evidence on the efficacy, safety and coverage related aspects regarding the use of miglustat in patients with Niemann-Pick disease type C. Two patients had adult-onset disease with neurologic and psychiatric manifestations. All of them reported the potential adverse effects of miglustat, i.

Niemann-Pick disease treatment: a systematic review of clinical trials

Three patients tipoo diagnosed postnatally, and the last 2 were diagnosed based on an affected sib. Cataplexy and other types of seizures may be found during the evolution of the disease. Niemann-Pick disease type C. Summary and related itpo. A total of 3, potential articles were identified, but only 15 of them were clinical trials performed in humans.

Niemann-Pick type C NP-C is a treatable inherited, irreversible and chronically debilitating neurovisceral disease with a minimal incidence previously estimated to be 1: I Conception and design: Other search option s Alphabetical list.

Mol Genet Metab ; The cerebral defect in Tay-Sachs disease and Niemann-Pick disease. Genotype-phenotype relationship of Niemann-Pick disease type C: Of the selected clinical trials, all but one reported common disease symptoms at baseline, i. Histologic analysis revealed that the characteristic neuronal storage pathology of NPC disease was substantially reduced in the double mutant mice. Niemann—Pick’s and Gaucher’s diseases. The metabolism of sphingomyelin.


Foam cells or sea-blue histiocytes are found on bone marrow biopsy. Given the chronic and progressive neurodegenerative nature of the disease and its low frequency, it is difficult tippo find evidence of high quality or with important targets. PLoS One ; 7: Use of a protein sequence of localisation and endolysosomal degradation. Furthermore, there is no uniformity among studies in treatment outcomes or in data analysis and presentation of results.

Welcome to NPC-info.com

Patients with more severe biochemical, cognitive, and symptom deficits performed most poorly on brainstem and frontal ocular xe measures.

Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1. Niemann Pick disease has been classified by some into type I and type II: La enfermedad de Niemann-Pick es hereditaria. The clinical spectrum of fetal Niemann-Pick type C. Regulation of low density lipoprotein receptor and 3-hydroxymethyl-glutaryl-CoA reductase activities are differentially affected in Niemann-Pick type C and type D fibroblasts. However, during the treatment epistaxis and thrombocytopenia, insomnia, leukopenia, behavioural problems, extrapyramidal symptoms, tremors, hypertransaminasemia, and especially weight loss or diarrhea, were detected in some patients.

We are determined to keep this website freely accessible. You are now leaving the NPC-info.