We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.
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Discussion We report the first outbreak of disease caused by an unusual fungal pathogen, A. Molecular typing of Aspergillus ustus isolates by using random amplification of polymorphic DNA. Aspergillus Fungi described in Like other members of the genus Aspergillusthe A.
Support Center Support Center. Although these toxins may be medically important, the quantities of toxin produced in the environment may not be significant 28 All members of the A. Some metabolites of A. Microscopically, the conidia are large 3. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported.
Fukuda T, Boeckh M, Carter RA Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic aspefgillus cell transplants after nonmyeloablative conditioning.
The conidia are 3. Whether death was attributable to the usrus infection, coinfections, or underlying diseases is unclear. Infections caused aspergillud A. Many reported cases have been either primary cutaneous disease or disseminated infection, however, we cannot draw firm conclusions regarding the types of infections this organism causes because of the high likelihood of reporting bias.
PCR products underwent electrophoresis in 1. The fungus is thought to spread through air and water, and be passed on surfaces where spores settle. These patients also possessed classic risk factors for IA in that most had graft-versus-host disease that required corticosteroid and other immunosuppressive therapy Bull Environ Hstus Toxicol.
It is commonly found in indoor environments and soil. Recognition of time-clustered cases in prompted us to do this retrospective study and epidemiologic investigation.
It is the main contaminant of cultivated soils but it occurs on other habitats:. In the and outbreaks, all case-patients resided in the same or adjacent rooms before diagnosis Figure 1. These outbreaks of A. We report here the first cluster of Aspergillus ustus endophthalmitis cases which occurred in a large tertiary care hospital during the period October to June Journal List Emerg Infect Dis v.
This page was last edited on 10 Septemberat Cases of infection caused by A. Susceptibility minimal effective concentration to caspofungin Merck Research Laboratories, Rahway, NJ, USA was determined by using a microbroth dilution assay in antibiotic 3 AM3 media, as described previously Cluster analysis was performed by the unweighted pair group mean with arithmetic average UPGMA method The conidia heads are columnar when mature with hemispherical or globose and generally pigmented vesicles.
Since these patients resided in rooms within close proximity, common source acquisition e. Three isolates from patient 5 were genetically most similar to the isolate from patient 2. Retrieved from ” https: Also, several patients who were not found to have A. Patient 5 and 6 resided in the same room at different times.
The latter may occur in A.
Aspergillus ustus – Wikipedia
Ascioglu S, Rex JH, de Pauw J Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: Our investigation was limited by constraints in conducting aspergillus analyses. Footnotes Suggested citation for this article: Its presence indicates a deficiency of the soil because it is highly destructive and grows where other species are unable to grow. Epidemiologic Investigation Estimating that patients were admitted for HSCT during the at-risk period, the highest overall attack rate was 1.
Of note, aslergillus of a new surgery pavilion occurred outside our hospital building beginning in July and ending in December Disseminated aspergillosis caused by Aspergillus ustus in a patient following allogeneic peripheral stem cell transplantation. Aspergillus ustus, antifungal drug resistance, emerging pathogen, outbreak, transplantation, research. Patients were in and out of the hospital after azpergillus, so infection could have been acquired in the environment. Aspergillus ustus is a microfungus and member of the division Ascomycota.
It is unknown whether ongoing hospital construction may have contributed to this cluster of cases.
The isolates recovered from the 5 HSCT were genetically similar. Patient 3 was in the outpatient clinic at the time of diagnosis and is, therefore, not marked on this inpatient spot map.